Medical Description of Flozen-Plus Tablet
The flozen-Plus tablet contains Diclofenac 50mg, Serratiopeptidase 15mg and Paracetamol 325mg is a pain-relieving medicine used to treat pain and swelling in conditions like rheumatoid arthritis, ankylosing spondylitis, and Osteoarthritis. It is also used to treat muscle aches, back pain, joint pain, and postoperative pain. The combination of this medicine produces its action by inhibiting the release of chemical substances which cause pain and inflammation in your body.
Flozen-Plus Tablet Benefits
Pain relief
The use of this tablet helps to relieve moderate to severe pain in conditions like menstrual cramps, headaches, joints, muscles, rheumatoid arthritis, and osteoarthritis by inhibiting the chemical messengers in the brain.
Mechanism of action of Flozen-Plus Tablet
Flozen-Plus tablet contains Diclofenac 50mg, Serratiopeptidase 15mg, and Paracetamol 325mg. Diclofenac is an analgesic and anti-inflammatory medication. It produces its action by inhibiting the cyclooxygenase (COX-1) and (COX-2). Thus it inhibits the synthesis of prostaglandins which is responsible for pain and inflammation. It also inhibits the aggregation and activation of neutrophil and chemotaxis, decreases the proinflammatory cytokine level, and alter the activity of lymphocyte.
Paracetamol is an analgesic and antipyretic. It produces its action by acting on the hypothalamus to produce antipyresis. It also works peripherally to block the pain impulse generation and it also inhibits the synthesis of prostaglandin synthesis in the central nervous system.
Serratiopeptidase is an enzyme that produces its action by breaking the abnormal proteins at the site of inflammation and it also promotes healing.
How Flozen-Plus Tablet works
Flozen-Plus tablet contains Diclofenac 50mg, Serratiopeptidase 15mg, and Paracetamol 325mg. Diclofenac is an analgesic and anti-inflammatory medication. It produces its action by inhibiting the release of chemical messengers which is responsible for pain and inflammation
Paracetamol is an analgesic and antipyretic. It produces its action by the release of chemical messengers which is responsible for pain and fever
Serratiopeptidase is an enzyme that produces its action by breaking the abnormal proteins at the site of inflammation and it also promotes healing.
FAQs for Flozen-Plus Tablet
- Can Flozen-Plus tablets damage your kidneys?
Long-term use of this medicine may cause renal damage such as protein or blood in urine and painful urination. Kindly monitor the patient's kidney function.
- Is the Flozen-Plus tablet a good painkiller?
Yes, the use of this tablet is considered an effective treatment to relieve pain and inflammation.
- Does the Flozen-Plus tablet make you drowsy?
Yes, the use of this tablet makes you feel drowsy, fatigue and drowsiness but it is considered a common effect.
Precautions and general warning of Flozen-Plus Tablet
Alcohol
It is considered unsafe to consume alcohol while taking this medication. Kindly consult with your doctor
Driving or operating machinery
It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consultwith your doctor.
Pregnancy
It is considered unsafe during pregnancy it may produce harmful effects on the fetus. Kindly consult with your doctor.
Breast Feeding
Limited information is available regarding the use of this medicine in patients during breastfeeding. Kindly consult with your doctor.
Kidney Problem
The tablet should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.
Liver Disease
The tablet should be used with caution in patients with severe liver impairment. The use of this medicine required dose modification. Kindly consult with your doctor.
General instructions
Diclofenac 50mg, Serratiopeptidase 15mg, and Paracetamol 325mg is a pain-relieving medicine used to treat pain and swelling in conditions like rheumatoid arthritis, ankylosing spondylitis, and Osteoarthritis. It is also used to treat muscle aches, back pain, joint pain, and postoperative pain. The combination of this medicine produces its action by inhibiting the release of chemical substances which cause pain and inflammation in your body.
Drug Interaction of Flozen-Plus Tablet
Drug-Drug Interaction
Apixaban + Diclofenac
The use of this drug is contraindicated because the combination of this drug increases the effect of anticoagulation
Captopril + Diclofenac
Use alternative drug because the use of the non-steroidal anti-inflammatory drug may decrease the effectiveness of the antihypertensive drug and the combination of these drugs also decrease the renal functions
Aliskiren + Diclofenac
Therapy should be administered with caution because the use of diclofenac will decrease the effect of aliskiren by other
Apalutamide + Acetaminophen
Therapy should be administered with caution because the use of apalutamide will decrease the effect of acetaminophen by increasing its elimination.
Eltrombopog + Acetaminophen
Therapy should be administered with caution because the use of eltrombopag increases the levels of acetaminophen by decreasing its metabolism.
Isoniazid + Acetaminophen
Isoniazid will increase the effect of acetaminophen by affecting its hepatic enzyme metabolism. Therapy should be administered with caution.
Colestipol + Acetaminophen
Colestipol decreases the effect of acetaminophen by inhibiting GI absorption. Use alternative drugs.
Drug-Food Interaction
Alcohol
The use of alcohol should be avoided in patients who are taking this medicine because it may increase the risk of bleeding in the stomach which includes tarry, bloody stools, or coughing up blood while vomiting. Do not withdraw the medication without consulting with the doctor
Drug-Disease Interaction
Asthma
Therapy should be administered with caution in patients who are having asthma because the use of the non-steroidal anti-inflammatory drug (NSAIDs) to an asthma patient may cause nasal polyposis, pansinusitis, eosinophilia, and rhinitis. Before initiating the therapy ask the patients whether they are allergic to salicylate salts.
Heart failure
Therapy should be administered with caution in patients with heart failure because the use of NSAIDs may cause fluid retention and edema
Hepatotoxicity
Therapy should be administered with caution in a patient with liver diseases because the use of NSAIDs may increase the serum transaminases, LDH, and alkaline phosphatase. And in rare cases, it may cause hepatotoxicity including liver cirrhosis, jaundice, and hepatic failure
Hypertension
Therapy should be administered with caution in patients with hypertension because the use of NSAIDs may increase blood pressure and cardiovascular events. During this course of treatment monitor the patient blood pressure
Renal toxicities
Therapy should be administered with caution in a patient with renal diseases because the use of NSAIDs may increase the serum creatinine, BUN, tubular necrosis, glomerulus, renal papillary necrosis, nephrotic syndrome, and cause renal failure.
Liver diseases + Acetaminophen
Therapy should be administered with caution in patients with hepatic insufficiency because severe liver injury including acute liver failure resulting in liver transplant and death has been reported in patients using acetaminophen. Patients with hepatic impairment may increase the risk of toxicity due to increased metabolic pathway activity. During acetaminophen-containing treatment, patients should avoid consuming alcohol.
Alcoholism + Acetaminophen
Therapy should be administered with caution in patients who are consuming alcohol because severe liver injury including acute liver failure resulting in liver transplant and death has been reported in patients using acetaminophen. During acetaminophen-containing treatment, patients should avoid consuming alcohol. The patient should immediately seek the hospital if they experience signs and symptoms of liver injury such as fever, rash, anorexia, nausea, vomiting, fatigue, dark urine, and jaundice.
